Maternal-Fetal Medicine Institute

Research

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Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution
Zhisheng Wu, Yiheng Wang, Wei-wei Chen, Hua Sun, Xiaoyan Chen, …, Yun Chen, Florent Ginhoux, Rongfeng Cui, Tianwen Huang, Hanjie Li
Cell  ·  01 Apr 2025  ·  doi:10.1016/j.cell.2025.02.007
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development
Zeshuai Wang, Zhisheng Wu, Hao Wang, Ruoqing Feng, Guanlin Wang, …, Yong Zeng, Florent Ginhoux, Xueqing Wu, Yuanfang Zhu, Hanjie Li
Cell  ·  01 Sep 2023  ·  doi:10.1016/j.cell.2023.08.019

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2026

The metabolic landscape of the maternal-fetal interface in missed miscarriage: a cross-sectional pilot multiomics study
The metabolic landscape of the maternal-fetal interface in missed miscarriage: a cross-sectional pilot multiomics study
Haoyue Hu, Qiqi Liu, Yingyu Liu, Jiao Cheng, Shuwei Zheng, Jing Ruan, Simin Liu, Yanfang Wang, Yuanfang Zhu, Xiaoyan Chen
F&S Science  ·  01 May 2026  ·  doi:10.1016/j.xfss.2026.01.001
Blood-based biomarker discovery for early pregnancy loss using integrative multi-omics strategies
Blood-based biomarker discovery for early pregnancy loss using integrative multi-omics strategies
Yue Shi, Yongkang Yang, Xianghao Guo, Shuai Shi, Qin Li, …, Yong Fei Wang, Xingqiang Lai, Yueqiong Ni, Xiaoyan Chen, Yao Wang
eBioMedicine  ·  01 May 2026  ·  doi:10.1016/j.ebiom.2026.106253

2025

Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome
Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome
Qingqing Yang, Simin Liu, Jing Ruan, Bo Sun, Xiaoyan Chen, Xingqiang Lai
Stem Cell Research  ·  01 Aug 2025  ·  doi:10.1016/j.scr.2025.103735
3D visualization of uterus and ovary: tissue clearing techniques and biomedical applications
3D visualization of uterus and ovary: tissue clearing techniques and biomedical applications
Qiqi Liu, Zhuo Song, Simin Liu, Zirui Dong, Xi Zheng, Tak Yeung Leung, Xiaoyan Chen
Frontiers in Bioengineering and Biotechnology  ·  07 Jul 2025  ·  doi:10.3389/fbioe.2025.1610539
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction
Wencheng Wei, Hao Wang, Li Fu, Hui Liu
Phytomedicine  ·  01 Jul 2025  ·  doi:10.1016/j.phymed.2025.156870
Recent advances in multimodal approaches for investigating placental development and related diseases
Recent advances in multimodal approaches for investigating placental development and related diseases
Hao Wang, Tao Zhang, Jing Ruan, Xi Zheng, Shuwei Zheng, …, Fen He, Bo Sun, Qi Zhang, Yuanfang Zhu, Xiaoyan Chen
Placenta  ·  09 May 2025  ·  doi:10.1016/j.placenta.2025.05.004
Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer
Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer
Chengbin Yang, Shiqi Tang, Qiqi Liu, Miaozhuang Fan, Wenguang Zhang, Yingyu Liu, Xin Chen, Gaixia Xu, Xiaoyan Chen, Zhourui Xu
iScience  ·  01 Apr 2025  ·  doi:10.1016/j.isci.2025.112196
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution
Zhisheng Wu, Yiheng Wang, Wei-wei Chen, Hua Sun, Xiaoyan Chen, …, Yun Chen, Florent Ginhoux, Rongfeng Cui, Tianwen Huang, Hanjie Li
Cell  ·  01 Apr 2025  ·  doi:10.1016/j.cell.2025.02.007
Infertility management in resistant ovary syndrome: a review
Infertility management in resistant ovary syndrome: a review
Hong Yi, Lin Chen, Jinglei Zhang, Yangxing Wen, Xi Zheng, Xiaoyan Chen
Frontiers in Endocrinology  ·  18 Mar 2025  ·  doi:10.3389/fendo.2025.1560981

2024

Co-culture Model Using Two Types of Adherent Cell Lines
Co-culture Model Using Two Types of Adherent Cell Lines
Zhuo Song, Lisha Zhao, Jingwen Hu, Xi Zheng, Yingyu Liu, Hao Wang, Xiaoyan Chen
Journal of Visualized Experiments  ·  08 Nov 2024  ·  doi:10.3791/67314
Inclusion of pregnant populations in clinical trials in China: the ethical considerations
Inclusion of pregnant populations in clinical trials in China: the ethical considerations
Xiaoyan Chen, Huifeng Shi, Barbara Wilkinson, Yuanfang Zhu
The Lancet Rheumatology  ·  01 Nov 2024  ·  doi:10.1016/S2665-9913(24)00276-5
Promoting the welfare of animals utilized in neuroscience research
Promoting the welfare of animals utilized in neuroscience research
Tianshuo Zhang, NianNian Zhang, Ruoqing Feng, Hao Wang, Fangfang Bi, Shuangqing Wang
Brain‐X  ·  01 Sep 2024  ·  doi:10.1002/brx2.70002
The role of the annexin A protein family at the maternal fetal interface
The role of the annexin A protein family at the maternal–fetal interface
Jingwen Hu, Lin Chen, Jing Ruan, Xiaoyan Chen
Frontiers in Endocrinology  ·  01 Mar 2024  ·  doi:10.3389/fendo.2024.1314214
Prenatal diagnosis of fetal intracranial medulloepithelioma: a case report
Prenatal diagnosis of fetal intracranial medulloepithelioma: a case report
Zhuo Meng, Lin Chen, Fangfang Chen, Shixin Fu, Hongkui Yu, Xiaoyan Chen
Frontiers in Neurology  ·  24 Jan 2024  ·  doi:10.3389/fneur.2023.1295408
Isolation of myeloid-derived suppressor cells MDSC from endometriotic mice model and their immunomodulatory functions
Isolation of myeloid-derived suppressor cells (MDSC) from endometriotic mice model and their immunomodulatory functions
Methods in Cell Biology  ·  01 Jan 2024  ·  doi:10.1016/bs.mcb.2023.04.004
Proangiogenic Macrophage Development in Human Prenatal Stage: A Key Element in Maternal-Fetal Medicine Puzzle
Proangiogenic Macrophage Development in Human Prenatal Stage: A Key Element in Maternal-Fetal Medicine Puzzle
Xiaoyan Chen, Hao Wang, Yuanfang Zhu
Maternal-Fetal Medicine  ·  01 Jan 2024  ·  doi:10.1097/FM9.0000000000000214

2023

Building a Better Silver Bullet: Current Status and Perspectives of Non Viral Vectors for mRNA Vaccines
Building a Better Silver Bullet: Current Status and Perspectives of Non‐Viral Vectors for mRNA Vaccines
Jiayu Gu, Zhourui Xu, Qiqi Liu, Shiqi Tang, Wenguang Zhang, …, Xiaoyan Chen, Jiajie Chen, Ken‐Tye Yong, Chengbin Yang, Gaixia Xu
Advanced Healthcare Materials  ·  15 Nov 2023  ·  doi:10.1002/adhm.202302409
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development
Zeshuai Wang, Zhisheng Wu, Hao Wang, Ruoqing Feng, Guanlin Wang, …, Yong Zeng, Florent Ginhoux, Xueqing Wu, Yuanfang Zhu, Hanjie Li
Cell  ·  01 Sep 2023  ·  doi:10.1016/j.cell.2023.08.019
Autophagy in Disease Onset and Progression
Autophagy in Disease Onset and Progression
aging and disease  ·  01 Jan 2023  ·  doi:10.14336/ad.2023.0815